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Divalproex is used to treat seizure disorders, certain psychiatric conditions (manic phase of bipolar disorder), and to prevent migraine headaches. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain. Take this medication by mouth as directed by your doctor. You may take it with food if stomach upset occurs. Swallow the tablet whole. Do not crush or chew the tablet, which can irritate the mouth or throat. The dosage is based on your age, weight, medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day to keep the amount of medication in your blood constant. If this medication is used for seizures, do not stop taking it without consulting your doctor. Your condition may become worse if the drug is suddenly stopped. Your dose may need to be gradually decreased.

Other names for this medication:
Divalproex, Depakote, Dicorate, Divaa, Desval,

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Extensive use of pressurized steam in the oil and gas sectors has led to incidents where workers were seriously injured. The maximum tolerated dose is 25 mg/m2 weekly given 3 of 4 weeks. Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation. Patients with acute stroke and severe unilateral cervical carotid stenosis/occlusion significantly have high incidence of intracranial stenosis and ROAF. Fundus examination revealed bilateral hypertensive and diabetic angiopathy.

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Bofutsushosan, an Oriental Herbal Medicine, Attenuates the Weight Gain of White Adipose Tissue and the Increased Size of Adipocytes Associated with the Increase in Their Expression of Uncoupling Protein 1 in High-Fat Diet-Fed Male KK/Ta mice. Depression may present itself in different ways among African Americans in the caregiving context, and results suggest information may be lost when global measures of depression are used. In order to achieve its goals, ASCO has an International Affairs Committee that oversees many programs that involve a global exchange of knowledge through courses and workshops, mentoring, initiatives promoting research, and specialty training standards. However, further studies with larger populations of patients with type 2 diabetes and chronic kidney disease are needed to clarify the efficacy and safety of the different treatment options, including newer drugs.

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Palliative results of aggressive surgery in recurrent abdominal malignancy: five illustrative cases. CD21 (C3dg/EBV receptor) is physically associated on B cells with a complex of proteins that includes CD19 and the widely distributed tetraspan 4 (TM4) family protein CD81 as well as other TM4 proteins (CD53, CD37 and CD82).

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This article provides a comprehensive review of syndromes, disorders, and maternal risk factors associated with NTDs, such as acrocallosal syndrome, autosomal dominant brachydactyly-clinodactyly syndrome, Manouvrier syndrome, short rib-polydactyly syndrome, Disorganization ( Ds )-like human malformations, isolated hemihyperplasia, X-linked NTDs, meroanencephaly, schisis association, diprosopus, fetal valproate syndrome, DiGeorge syndrome/velocardiofacial syndrome, Waardenburg syndrome, folic acid antagonists, diabetes mellitus, and obesity. Both organelles exhibit remarkable structural dynamism and UPS control is particularly concerned with these properties. On the use of central nervous system stimulators in anesthesiologic practice The development of computer-assisted learning software packages is a relatively new field of computer application.

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High concentrations of guide-RNA:Cas9 complexes can cleave off-target sites containing mutations near or within the PAM that are not cleaved when enzyme concentrations are limiting. Owing to the intrinsic hydrogeological settings and rainfall intensity, the threshold of size for the suspended particle was 4 pm in Qingmuguan groundwater system. are the predominant organisms in the intestinal tract, and they also are important opportunistic pathogens.

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Multi-drug resistant toxigenic Vibrio cholerae O1 is persistent in water sources in New Bell-Douala, Cameroon. Tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells were considered as osteoclasts, and the resorption area was determined by incubating the cells on dentine discs. Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome. Evidence supporting partial oral therapy as an alternative to the routinely recommended continued parenteral therapy is scarce, although observational data suggest that this strategy may be safe and effective. MARCKS (myristoylated alanine-rich C-kinase substrate) is a major substrate for protein kinase C (PKC), a kinase that has multiple functions during oocyte maturation and egg activation, for example, spindle function and cytoskeleton reorganization.

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All patients were assessed independently by 2 specialist physicians. To examine the role of chromatin regulation in stem cells in vivo, we study regeneration in the freshwater planarian Schmidtea mediterranea. Between March 1987 and April 2001, 65 patients with stage I pure testicular seminoma received adjuvant radiotherapy with a 25 MV linear accelerator.

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Representations of target-defining features (attentional templates) guide the selection of target objects in visual search. Rats were killed after a successful modeling in the twelfth week, then tested blood low-density lipoprotein, high density lipoprotein, and the coronary artery intima-media thickness. In patients with positive results from serologic tests for celiac disease, analysis of tissues samples from the duodenal bulb, in addition to those from other parts of the small bowel, might increase the diagnostic yield. To determine the most adequate number and size of tissue microarray (TMA) cores for pleomorphic adenoma immunohistochemical studies.

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The liver is a common site of both primary and secondary malignancy resulting in significant morbidity and mortality. From secondary prevention to primary prevention: a unique strategy that gives hope to a country ravaged by meningococcal disease. Comparative results of the amplification with the new and the previously described primers proved that with this new primer there is a substantial increase in the specificity of the amplification. Different laboratoristic predictors were also reviewed: ECG-derived predictors, among which we separately evaluated those derived from the 12-lead surface ECG and those derived from the signal averaged P-wave, and other electrophysiologic predictors as atrial monophasic action potential analysis.

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Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial. A chest roentgenogram and computed tomography (CT) scan showed a right-sided mediastinal shift. Treatment of this condition includes both surgical and nonsurgical options.

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Much existing knowledge has been derived from computer simulations of idealized model systems containing spherical particles interacting with well-defined pair potentials. Knowledge gained from this study contributes to the understanding of the ecology of insect pests in prune orchards. Since the changes in free crosslinks during treatments with newer BPs containing amino residues is subtle, the advantage of measurement of N-telopeptide (NTX) has been reported elsewhere.

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A total of 108 patients who underwent nonsurgical therapy as the first choice of treatment were derived from consecutive clinical series of patients registered in one medical center renowned for their use of percutaneous ethanol injection. We previously identified several promoter elements that regulate 21-OHase gene expression in mouse Y1 adrenocortical tumor cells. Cryogenic radiolytic reduction is one of the most straightforward and convenient methods of generation and stabilization of reactive iron-oxygen intermediates for mechanistic studies in chemistry and biochemistry.

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Ischemia-induced SCI resulted in significant reduction of Tarlov scores and a significant decline in number of viable neurons. Many patients will likely need to eclipse the 800 mg threshold and pharmacies and insurance companies should be aware of the requirements that may extend beyond approval limits. Early postoperative data and most recent follow-up data are presented if available. Just only preliminary observes the clinical effect, a small sample size. Furthermore, the immune protective efficacy of the spaA-chimeras was demonstrated by lethal challenge with a virulent homologous strain 1249 against immunized mice.

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The root is crucial for the physiological function of the tooth, and a healthy root allows an artificial crown to function as required clinically. Results showed that for hand responses motor priming effect was stronger when the hands were free, whereas for foot responses it was stronger when the hands were bound. Evidence for equivalent function in culturally distinct motor skills. In previous experiments examining this question, alternative phenotypes have not been presented to ecologically relevant predators, and the results are thus potentially confounded by the presence of sharp, bony fin spines in these species, which may also represent significant deterrents to predation. One program, multiple training sites: does site of family medicine training influence professional practice location?

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In asthmatic patients, we showed that the ability of AM to transform LTC4 into its derivatives LTD4 and LTE4 was related to the intensity of the local inflammation observed during endoscopy. The neuro-ophthalmic evaluation showed a subclinical reduction of RNFL average thickness provided by OCT and an increase of P50 and N95 latency by pattern electroretinogram.

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During backward flexion, initial motion started from the lower segments to the upper segments. Also, the volar locked plate was stiffer than the dorsal nonlocked plate for all loading configurations tested except when subjected to a dorsally applied eccentric load.

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They were asked to rate their level of agreement on statements related to hands-on/hands-poised techniques, the association of hands-poised/hands-off approach with OASIS, the need to implement perineal support and the need to improve the evidence to support it. Furthermore, Notch target genes were expressed at low levels in primitive hematopoietic progenitors. Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits. Using single or multiple 17 gauge cryoneedles or 3.0 mm cryoprobes and 2 freeze-thaw cycles (10-minute freeze and 5-minute thaw) 13 acute and 10 chronic cryolesions were made. The advantage of freeze-drying is that it allows long-term storage at room temperature.

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Coatings with a thick film and/or low amylose content were relatively impermeable and able to delay drug release under conditions mimicking the upper gastrointestinal tract. Profile of gynecologic malignancies reported at a tertiary care center in India over the past decade: comparative evaluation with international data. This study also provides a safe and effective treatment/monitoring protocol that should readily translate to humans.

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The effect of oral ondansetron in the prevention of postoperative nausea and vomiting Healthy ageing to middle age is associated with diminishing sensitivity to meal ingestion of visual food cue-evoked activity in brain regions that represent the salience of food and direct food-associated behaviour. It examines this conceptualization in the context of a health system pursuing several major initiatives to capture insights into the nature of such interdependencies. Maternal myasthenia gravis has been associated with the presence of neonatal myasthania and sometimes fetal congenital anomalies.

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A comparison of negatively and positively charged liposomes containing entrapped polyinosinic-polycytidylic acid for interferon induction in mice. Increased accessibility of resources tailored for hospital respirator program administrators may be helpful. The importance of competency domains was assessed by using a 5-point Likert scale.

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To evaluate the capacity of natural latex membrane to accelerate and improve the regeneration quality of the of rat sciatic nerves. No other author has a financial or proprietary interest in any material or method mentioned. In addition, we report that ORF 3a is both necessary and sufficient for SARS-CoV-induced Golgi fragmentation and that the 3a protein accumulates and localizes to vesicles containing markers for late endosomes.

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Collagenolysis and cellular death are a prelude to stigma formation and ovarian rupture. Especially in DL110, the activation increased in a dose-dependent manner. Starting from a model for neighbor independent nucleotide substitution we successively added neighbor-dependent substitution processes in the order of their ability to increase the likelihood of the model describing given data. Comparing the iP rat to the iNP rat, quantitative real-time polymerase chain reaction detected significantly decreased levels of NPY mRNA expression in the iP rat in the six brain regions tested: nucleus accumbens, frontal cortex, amygdala, hippocampus, caudate-putamen, and hypothalamus. Correlations between bactericidal action and inhibition of bacterial metabolism, and also between bactericidal action and chemical structure of the detergents are discussed.

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Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment. Previous studies have reported different results about the effect of early post cesarean feeding on vomiting, nausea, flatulence and illus.

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STAG2 expression in oral cancer and potentially malignant lesions. Subjects were 1167 community-dwelling Japanese men and women, aged 40-79 years. The proenkephalin A mRNA response to stress in the pPVN was maintained, implying a specific inhibition of the CRF mRNA responses in this pathological situation.

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Pineal melatonin and the innate immune response: the TNF-alpha increase after cesarean section suppresses nocturnal melatonin production. The aim of the study was to analyse the cases of nephrolithiasis in the youngest children from 2 months and 4 years. Unfortunately, the mortality risks of muscle loss may outweigh the potential benefits of weight loss in the elderly. Herein the authors present a case of a 46-year-old male patient with cirrhosis and complications of high-volume chylous ascites and chylothorax who was successfully treated with creation of a transjugular intrahepatic portosystemic shunt. Extended periods of deafness have profound effects on central auditory system function and organization.

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Profile comparison methods have been shown to be very powerful in creating accurate alignments of protein sequences, especially in the case of remotely related proteins (RRP). The aim of this study was to determine the relationship between selected biochemical parameters, bone turnover markers, clinical parameters and bone mineral density (BMD) in postmenopausal women with osteoporosis. Measurements of the exit dose and evaluations of the optical density of portal films can be used to verify and document the energy of electron beams during radiotherapy.

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Plasma glucose, MDA, fructosamine, and glycated hemoglobin were analyzed in both the groups. We also investigated the impact of SO emulsification on the expression of apoptotic factors. Ovariectomy resulted in lower cancellous BV/TV and Ct.Ar and higher cancellous, endocortical, and periosteal MS and BFR.

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This paper examines the benefits of providing a tax credit to encourage companies to conduct preclinical research on neglected diseases in the laboratory or in animals. A novel theoretical model based on superposition of core and shell band-gaps, termed as SQCE model, is developed and reported here, which enables one to estimate the shell thickness in a core-shell quantum dot (QD), which is critically important in deciding its optical and electronic properties.

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Human papillomavirus type 6 was the only HPV type detected in these tumor DNAs by Southern blot hybridization and by the polymerase chain reaction using both consensus and type-specific primers. In patients having a vaso-occlusive crisis both HbSS and HbSC patients showed significantly enhanced serum IL-8 levels compared to healthy controls. From these results it is concluded that the CRF and E-WN Ucn neuronal systems work in concert in response to acute challenges, but are inversely regulated in their activities during chronic hyperactivity of the hypothalamo-pituitary-adrenal axis. Despite numerous studies of the defense against reactive oxygen species (ROS) during reproduction, very little is known about the damage caused by ROS to the tissues of wild breeding animals. This latency is not affected by large depolarizing or hyperpolarizing changes in membrane potential.

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The aim of study was evaluation of early enteral nutrition application in critically ill patients in medical intensive care unit. Photoinduction of surface-relief gratings during all-optical poling of polymer films.

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Treatment with STF-62247 did not alter cell cycle progression but when combined with radiation increased cell killing under oxic and hypoxic/physiological conditions. Studying the mechanism of coronary development will contribute to the understanding of the disease and help design new diagnostic or therapeutic strategies. Adaptation of muscle fibers of warm water Rana ridibunda to temperature factors In conclusion, these results suggest that HET0016 protects BBB dysfunction after I/R by regulating the expression of MMP-9 and tight junction proteins.

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To determine the frequency and leading factors of pulmonary hypertension among chronic hemodialysis patients. This is a randomized, controlled trial of 50 low-income postpartum women who desired LARC. Survival was associated with mitotic score, but not with nuclear pleomorphism on both univariate and multivariate analysis. Historically, inequities have existed between male and female physicians in professional advancement, but evidence has suggested that disparities in salary are resolving.

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The conjugate was shown to be specifically internalized into folic acid receptor expressing cells. Various theoretical explanations of NDEs were examined to account for these findings. The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia. A refraction model is developed and applied to the analysis of data collected from the experiment.

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Tunable chemokine production by antigen presenting dendritic cells in response to changes in regulatory T cell frequency in mouse reactive lymph nodes. The trend to search novel microbial natural biocides has recently been increasing in order to avoid the environmental pollution from use of synthetic pesticides.

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The aging of the 2000 and 2011 Hallmarks of Cancer reviews: a critique. Given these data establishing the potency of cyclin D1-mediated repression, we evaluated the ability of cyclin D1 to inhibit tumor-derived AR alleles and polymorphisms associated with tumor progression and increased prostate cancer risk. This article reviews how network pharmacology can help in the identification of druggable avenues in TFs and also allow the selection of drugs and their synergistic pairs against HNFs for cancer therapy. This method should be useful not only to detect the SNs but to visualize pathways other than through the hilar lymph nodes. Additionally, we consider both passive thermal and active motor-driven processes within the cell and demonstrate through modeling how active internal fluctuations are modulated via dimensionality.

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We addressed this issue by examining the role of stimulus element orientation bandwidth in contour integration, a previously unexplored area. We could show that this rule can be used to genetically engineer a protein to study the biological relevance of the presence or absence of an acetyl group, thereby generating a generic assay to probe the functional importance of N-terminal acetylation. Future development of these techniques could open up novel applications in terms of molecular diagnosis and therapy monitoring in MS patients. There is insufficient evidence that TSM is more effective in reducing pain and disability than control treatments in patients with non-specific neck pain. Effects of desoxycorticosterone and ACTH on respiration justaucorps danse classique vicard medicine of various tissues

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Lethal herpesvirosis in 16 captive horned vipers (Vipera ammodytes ammodytes): pathological and ultrastructural findings. Iron(III)/ascorbate toxicity was completely prevented with the hydrogen peroxide detoxifying enzyme catalase and partially prevented with the antioxidant vitamin E. Community-based interventions are often not conducted or evaluated in controlled settings, yet they provide more real-world context and have the potential to have a greater effect on population health than findings from controlled studies that are limited in escitalopram anxiety and depression generalizability. No interferences were observed during analysis of patient samples obtained prior to idebenone treatment.

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Some tests can be used to monitor antiplatelet therapy and assess risk of bleeding and thrombosis, although current guidelines advise against this. To study DNA strand breaks induced by direct energy deposition by photo- dosage for mebendazole and Auger electrons ejected following K-shell photoabsorption of DNA constituent atoms (carbon, nitrogen, oxygen and phosphorus). All patients were evaluated at baseline and at completion of the pulmonary rehabilitation program by using 3 instruments: the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and 6-minute walk distance (6MWD). Contribution of a virtual hysteroscopic simulator in the learning of hysteroscopic myoma resection

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In the developing heart, Notch signaling plays an essential role in several key developmental processes, such as epithelial-to-mesenchymal transition and myocyte proliferation and differentiation. The clopidogrel prices philippines influence of knowledge about the macronutrient content of foods on dietary habits is poorly understood. Physicochemical studies evidenced the interactions between HNT and sodium alkanoates, ruled out clay exfoliation, quantified the amount of the loaded substance, and showed an increase of the total net negative charge, allowing us to obtain rather stable aqueous nanoclay dispersions. The simulation data obtained provide for the first time insight into the dynamics of amphoteric sample components that do not focus within the established pH gradient. BAPTA induces a decrease of intracellular free calcium and a translocation and inactivation of protein kinase C in macrophages.

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Tracheal reconstruction after extensive resection remains an unsolved surgical problem. Intravenous clonidine infusion in critically ill children: dose-dependent sedative effects and cardiovascular stability. From the similar action of calcium and copper chlorides the effective combining power of gelatin for complex positive ion formation is deduced. We have also investigated the trimol syrup norman role of insulin in the expression of the major PNS myelin glycoprotein P zero (P0) in normal as well as high glucose conditions in primary rat Schwann cells.

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Commonly ishape mattress ishape lotus 12 inch queen size cool gel memory foam mattress draining the kidney with nephrostomy is the only method for the patients. However, little is known about the interactions between the different instantiations of the ANS and in how many ways they are related to exact calculation. However, the expression levels of most genes were not dramatically changed except BmEts expression increased approximately 8.0-fold 12h after BmNPV infection.

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The effects of three different audiotapes, containing different kinds of social comparison information, were examined. s-HJV is reduced klacid clarithromycin doses in the cleavage mutant R335Q as well as in cells treated with a furin inhibitor, and increased in cells overexpressing exogenous furin, but not in cells overexpressing an inactive furin variant. Femoropopliteal bypass using endoscopic vein harvest is a durable reconstructive vascular procedure which can be performed with minimal postoperative morbidity, short LOS, and satisfactory long-term patency.

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These genes, induced in energy or hypoxia stressed cells, have been implicated in cell death pathways, and may provide important clues to the mechanism of SB-induced, leukemic cell death. Computed tomography and magnetic resonance imaging were useful carlos alves zucon medicine in demonstrating the location and extent of the buccomasseteric masses.

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Pharmacokinetic model to describe the lymphatic absorption of r-metHu-leptin after subcutaneous injection to sheep. This chapter introduces the fundamental concepts of discrete dynamic modeling, particularly focusing on Boolean dynamic models. The distribution of intensity was somewhat polarized, and substantial volumes of nonspecific training were undertaken. Model results suggest, that a full sewage treatment in Szczecin would allow the establishment of new beaches closer rifafour ingredients in meth to the city (north of Dabie lake).